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MedChemExpress References: PMID: 32183148 3-mercaptopyruvate sulfurtransferase (3-MST) has emerged as one of the significant sources of biologically active sulfur species in various mammalian cells. Luanpitpong, S. et al. J. By interacting with proteins, ROS have an impact on several signaling pathways involved in the control of cell proliferation and apoptosis. Weinberg, E. D. The role of iron in cancer. MeSH Med. ATP is accumulated by a synthase driven by a proton gradient generated in mitochondria by the NADH-dependent electron transport chain136,137; therefore, one possible way to overcome efficient efflux in cancer drugs is to inhibit ATP synthesis by promoting NADH conversion to NAD through lipid membrane-coated silica carbon nanoparticles that, under near-infrared laser irradiation, target mitochondria and produce ROS with simultaneous consumption of NADH138. 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Among tyrosine kinase inhibitors, imatinib (a PDGFR inhibitor) and erlotinib (an EGFR inhibitor) induce ROS-dependent apoptosis in melanoma and non-small-cell lung cancer cells, respectively, through disruption of mitochondrial membrane potential upon the stimulation of JNK and p38 phosphorylation88,89, while vemurafenib (a BRAF inhibitor) increases the production of superoxide anions with the commensurate depolarization of the mitochondrial membranes in melanoma cells90. Tumori Journal 96(6):985992, Zhang S et al (2012) The roles of hypoxia-inducible factors in regulating neural stem cells migration to glioma stem cells and determinating their fates. Since Fe(II) catalyzes the Fenton reaction to produce the free radical OH* from hydrogen peroxide, its upregulation presents a paradox: Nrf2 also boosts the expression of the genes encoding several components of the ferritin complex that detoxifies Fe(II) by converting it to Fe(III) and then stores it22. 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ROS has been found to be a major role player behind the sustenance as well as degradation of these cancer stem cells, making it a double-edged sword. 9 PDF View 1 excerpt, cites results Advancements in Polymeric Nanocarriers to Mediate Targeted Therapy against Triple-Negative Breast Cancer. Cell Metab 17(3):372385, Gandhi UH et al (2014) Selenium suppresses leukemia through the action of endogenous eicosanoids. ros modulate various cell signaling pathways, which are primarily mediated through the transcription factors nf-b and stat3, hypoxia-inducible factor-1, kinases, growth factors, cytokines and other proteins, and enzymes; these pathways have been linked to cellular transformation, inflammation, tumor survival, proliferation, invasion, As mentioned above, another central player in these redox systems is thioredoxin, which is reduced by NADPH to induce the transfer of electrons for use in DNA synthesis, signal transduction and redox regulation. 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Moreover, the use of drugs affecting mitochondria, where more than one-half of all ROS are generated, represents a suitable approach to induce oxidative stress and PCD in cancer cells109: gamitrinib, an inhibitor of heat shock protein 90 (HSP90), induces a dramatic collapse of mitochondria in prostate cancer cells110, while ARQ 501 (a quinone derivative) and STA-4783 (a copper chelator) increase ROS through leakage in the electron transport chain and have beneficial effects in patients with solid tumors and pancreatic adenocarcinoma111. sharing sensitive information, make sure youre on a federal Med. Wiel, C. et al. Cancer Med 5(9):25442557, Tang DG (2012) Understanding cancer stem cell heterogeneity and plasticity. ROS production was increased with temperature in cancer cells, but not in normal cells; this increase was potently inhibited by ascorbic acid. A., Booth-Genthe, C. & Gottesman, M. M. Targeting multidrug resistance in cancer. USA 107, 41534158 (2010). PubMed Central Read more about how to correctly acknowledge RSC content. ROS generated after the formation of ceramide or after an increase in energy metabolism induced by several receptor-interacting protein kinases (RIPs), either in the mitochondrial ETC and/or by NOXs, have been reported to enhance necroptosis123,124,125. Reactive oxygen species and cancer paradox: To promote or to suppress? Careers. CAS ROS are produced in mitochondria (mainly via the electron transport chain, where ~1-2% of O 2 is reduced to form superoxide anions), peroxisomes (through the -oxidation of fatty acids) and the. Biochem Pharmacol 148:6474, Wu S et al (2019) Nrf2 in cancers: a double-edged sword. Br J Cancer 109(7):18761885, Liu Y et al (2013b) Low-dose triptolide in combination with idarubicin induces apoptosis in AML leukemic stem-like KG1a cell line by modulation of the intrinsic and extrinsic factors. Reactive oxygen species in redox cancer therapy. Huang, L. E., Gu, J., Schau, M. & Bunn, H. F. Regulation of hypoxia-inducible factor 1 is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Macrophage and neutrophils-mediated immune responses involve the production and release of NO, which inhibits viruses, pathogens and tumor proliferation. Many answers have been found, and many questions still remain in oblivion. ]; P.O.R-Regione Calabria [Progetto Razionale to A.M.]. In conclusion, resveratrol has antiproliferative effect in bladder tumour cells and its mechanism of action occurred through ROS production, interference with cell cycle, and inhibition of cell migration, independent of TP53 status. Chem. 2013 Dec;62:107-19. doi: 10.1016/j.fct.2013.08.035. Med. The inherent cellular level of reactive oxygen species: one of the mechanisms determining the apoptotic susceptibility of leukemic cells to arsenic trioxide. Proc Natl Acad Sci 110(14):56065611, Zhang B et al (2016) Ultrasensitive and selective assay of glutathione species in arsenic trioxide-treated leukemia HL-60 cell line by molecularly imprinted polymer decorated electrochemical sensors. Several noncancer cells associate with tumors: among these, cancer-associated fibroblasts (CAFs), particularly represented in the tumor microenvironment (TME), actively contribute to the regulation of tumor homeostasis, promoting tumor progression and the invasion of cancer cells. Nat. Antioxid Redox Signal 16(11):12151228, Shi Q et al (2015) Sevoflurane promotes the expansion of glioma stem cells through activation of hypoxia-inducible factors in vitro. Wang, L. et al. Perillo, B., Di Donato, M., Pezone, A. et al. A novel platinum complex containing a piplartine derivative exhibits enhanced cytotoxicity, causes oxidative stress and triggers apoptotic cell death by ERK/p38 pathway in human acute promyelocytic leukemia HL-60 cells. Finally NO acts on vessels to regulate blood flow which is important for the adaptation of muscle to prolonged exercise. 357, 241247 (2001). Anticancer Res 23(5a):39853990, CAS Bruno Perillo. Med. Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism. 2017EKMFTN_002 to G.C. https://doi.org/10.1038/s12276-020-0384-2, DOI: https://doi.org/10.1038/s12276-020-0384-2. Epub 2017 Jan 11. 43, 6793 (2009). Nature 403, 4145 (2000). Cancer Med 8(5):22522267, Xia H et al (2013) MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer. Signal. Giovanni Galasso is supported by a fellowship of P.R.I.N. As noted above, chemotherapy and radiotherapy cause an increase in intracellular ROS that can lead to apoptosis92,93 via extrinsic or intrinsic pathways94,95. 313, 201210 (2011). and transmitted securely. Nature 520, 5762 (2015). Egger, G., Liang, G., Aparicio, A. HHS Vulnerability Disclosure, Help Matsushima, S. et al. Our results suggest that scabertopin can induce RIP1/RIP3-dependent necroptosis in bladder cancer cells by promoting the production of mitochondrial reactive oxygen . Int. Proc. Rapamycin was lung cells that low-dose acute acrolein exposures (3-27 mM, demonstrated to inhibit acrolein-induced apoptosis in male germ 30-60 min) could be overcome by an adaptive response involv-cells by alleviating acrolein-induced ROS, and reducing ROS- ing activation of antiapoptosis survival factors AKT and cIAP1/2, driven . In fact, it has been found that the breast cancer susceptibility 1 (BRCA1) gene interacts with and induces Nrf2 expression with positive outcomes on cancer cell survival63. Regulation of autophagy by ROS: physiology and pathology. Al-Hajj M et al (2003) Prospective identification of tumorigenic breast cancer cells. 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