The change in body weight from baseline to week 68 was 15.3 kg in the semaglutide group as compared with 2.6 kg in the placebo group (estimated treatment difference, 12.7 kg; 95% CI, 13.7 to 11.7) (Fig. Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents. The library also provides wide online access to NYT in other resources. Int J Obes (in press). From 2008, The "Times" in full-image content of every page. The design has been published previously.15 The trial was conducted in accordance with the principles of the Declaration of Helsinki and Good Clinical Practice guidelines. S3). The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams. The remaining 5 training sessions each week were performed unsupervised at home. Methylprednisolone for Heart Surgery in Infants A Randomized, Controlled Trial K.D. 27. Produced by Australian PT association. Find latest news from every corner of the globe at Reuters.com, your online source for breaking international news coverage. ); the Departments of Internal Medicine/Endocrinology and Population and Data Sciences, University of Texas Southwestern Medical Center (I.L. Hearst Television participates in various affiliate marketing programs, which means we may get paid commissions on editorially chosen products purchased through our links to retailer sites. IMST indicates inspiratory muscle strength training. Mild acute pancreatitis (according to the Atlanta classification18) was reported in three participants in the semaglutide group (one participant had a history of acute pancreatitis, and the other two participants had both gallstones and pancreatitis); all recovered during the trial period. Search and browsing the E-Journal Portal is free to all. Information and tools for librarians about site license offerings. 1-800-242-8721 Epub 2020 Aug 12. Adverse events caused treatment discontinuation in 4.3%, 7.1%, 6.2%, and 2.6% of participants receiving 5-mg, 10-mg, and 15-mg tirzepatide doses and placebo, respectively. Identified through searches of MedDRA, these preferred terms were judged to be relevant for each of the safety focus areas. This will provide an early assessment of the safety of a third dose of BNT162, as well as its immunogenicity. more. U.S. Department of Health and Human Services, The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Topics include Consumer Guides, Money and Taxes, and Benefits and Grants. 2020 (https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/209637s003lbl.pdf). Even as recently as this summer, people were saying, Oh, Covid doesnt spread in schools, and there was a misconception that kids dont get Covid, said Dr. Raifman, who was not involved in the new research. Boostability and protection-against-VOCs existing participant subset only: Participants who provided a serum sample at Visit 3, with Visit 3 occurring within the protocol-specified window. This database is freely available to any user with a computer and Internet connection. Neither subject dropped out because of treatmentrelated adverse events. S7). Collection of filmed pay productions from the British National Theatre available as streaming videos. This article is commented on by the following: Epidemiology of cardiovascular disease in the United States: implications for the perfusion profession. Topic Guides are available for: ProQuest Social Science Journal Collection is a definitive resource for those who need access to a variety of scientific journals. A subgroup of participants with a BMI of 40 or less underwent dual-energy x-ray absorptiometry (DXA) to assess body composition. Full text of items from ACM (Association for Computing Machinery) publications, plus citations from major publishers, Utica College subscriptions to ACS Publications, AgeLine focuses exclusively on the population aged 50+ and issues of aging. It has been reported that highresistance IMST reduces sympathetic activity in patients with obstructive sleep apnea, either measured directly with microneurography34 or using plasma norepinephrine concentrations.33 Our results do not show an obvious role for reductions in sympathetic activity contributing to improvements in cardiovascular function in our otherwise healthy midlife/older adults with abovenormal SBP. Flowmediated dilation and cardiovascular event prediction: does nitric oxide matter? Get clinically-studied, premium vitamins and supplements and lab tests from the people whove spent 40 years passionately pursuing healthy living. Individual Participant Data (IPD) Sharing Statement: Studies a U.S. FDA-regulated Drug Product: Studies a U.S. FDA-regulated Device Product: As a 2-dose (separated by 21 days) schedule; At various different dose levels in Phase 1; In 3 age groups (Phase 1: 18 to 55 years of age, 65 to 85 years of age; Phase 2/3: 12 years of age [stratified as 12-15, 16-55 or >55 years of age]). Epub 2020 Dec 10. OED traces the usage of words through 2.5 million quotations from a wide range of international English language sources, including classical literature, specialist periodicals, film scripts and cookbooks. Updates and new developments, http://ezproxy.utica.edu/login?url=https://dsm.psychiatryonline.org/. The main role of disease surveillance is to predict, observe, and minimize the harm caused by outbreak, epidemic, and pandemic situations, as well as increase knowledge about which factors contribute to such circumstances. Subject coverage includes: Designed for use by secondary school students and teachers, MAS Ultra provides access to many timely articles on a wide variety of topics suitable for student projects. Largest fully searchable database: government documents, federal/state law/cases, journals, with comprehensive coverage. more. Provides users with a comprehensive guide to over 2,700 contemporary testing instruments in several fields. Semaglutide was associated with greater reductions from baseline than placebo in waist circumference (13.54 cm with semaglutide vs. 4.13 cm with placebo; estimated treatment difference, 9.42 cm; 95% CI, 10.30 to 8.53), BMI (5.54 with semaglutide vs. 0.92 with placebo; estimated treatment difference, 4.61; 95% CI, 4.96 to 4.27), and systolic and diastolic blood pressure at week 68 (Table 2, Table S2, and Figs. This is a system organ class. Data are meanSEM. Our laboratory's daytoday CVs for 24hour SBP and DBP are 2.5% and 3.3%, respectively. The study is perhaps the best scientific evidence to date on the efficacy of masks. Numerous test tube and animal experiments as well as human clinical trials have shown that tulsi has anti-diabetic activity. Kurhade C, Zou J, Xia H, Liu M, Yang Q, Cutler M, Cooper D, Muik A, Sahin U, Jansen KU, Ren P, Xie X, Swanson KA, Shi PY. As a historical dictionary, OED entry structure is different from dictionary of current English. Mean 24hour DBP was unchanged in the IMST group (baseline: 752mmHg, endintervention: 742mmHg; P=0.63) and increased modestly in the sham group (baseline: 742mmHg, endintervention: 782mmHg; P=0.04). 12. Overall, 94.3% of the participants completed the trial, 91.2% had a body-weight assessment at week 68, and 81.1% adhered to treatment (Fig. The discovery and development of liraglutide and semaglutide. ), Leicester all in the United Kingdom; Novo Nordisk, Sborg, Denmark (S.C., M.T.D.T., N.Z. more. However, it should be noted that our findings are consistent with previous observations that FMDBA rapidly returns to baseline levels after terminating aerobic exercise training.82, 83 Further investigation will be needed to gain insight into the mechanisms underlying the differential SBP and FMDBA responses to cessation of IMST. 90 Day embargo. Roughly 4,860 participants finished the experiment, the Times reports. Casual DBP was 822mmHg at baseline versus 813mmHg after 6weeks of IMST in men (P=0.16) and 763mmHg at baseline versus 743mmHg after IMST in women (P=0.01). A complete list of investigators in the STEP 1 trial is provided in the Supplementary Appendix, available at NEJM.org. QUICK TAKEWeekly Semaglutide in Adults with Overweight or Obesity01:46, Obesity is a chronic disease and global public health challenge.1-3 Obesity can lead to insulin resistance, hypertension, and dyslipidemia,4 is associated with complications such as type 2 diabetes, cardiovascular disease, and nonalcoholic fatty liver disease,2,5 and reduces life expectancy.6 More recently, obesity has been linked to increased numbers of hospitalizations, the need for mechanical ventilation, and death in persons with coronavirus disease 2019 (Covid-19).7,8, Although lifestyle intervention (diet and exercise) represents the cornerstone of weight management,1,2 sustaining weight loss over the long term is challenging.9 Clinical guidelines suggest adjunctive pharmacotherapy, particularly for adults with a body-mass index (BMI, the weight in kilograms divided by the square of the height in meters) of 30 or greater, or 27 or greater in persons with coexisting conditions.1,2,10 However, the use of available medications remains limited by modest efficacy, safety concerns, and cost.3, Semaglutide is a glucagon-like peptide-1 (GLP-1) analogue that is approved, at doses up to 1 mg administered subcutaneously once weekly, for the treatment of type 2 diabetes in adults and for reducing the risk of cardiovascular events in persons with type 2 diabetes and cardiovascular disease.11 Semaglutide induced weight loss in persons with type 2 diabetes and in adults with obesity who were participants in a phase 2 trial,12-14 findings that supported further investigation. NYS Newspapers limits searching to just New York State newspaper content. Drug-induced hyperkalemia is the most important cause of increased potassium levels in everyday clinical practice. Healthy lifestyle practices can decrease cardiovascular disease risk, but adherence is low. This bibliographic database covers scholarly research in all major fields of philosophy, including related interdisciplinary fields such as education, anthropology, history, political science, science, law and religion. Drug-induced hyperkalemia may be asymptomatic. American Diabetes Association. The Serials Directory contains over 184,000 US and international titles, including: Offering more peer-reviewed, full-text journals than any other sociology research database, Sociology Source Ultimate provides the must-have materials for students studying social behavior and interaction. Ms. Buckmans son has autism, she added, and he was terrified of Covid. The sponsor (Novo Nordisk) designed the trial and oversaw its conduct. The average number of training sessions completed by the IMST group was 39.75.2 and by the sham group was 37.44.3, with no difference in the number of training sessions between groups (P=0.17). Methods and Results. ProQuest Newspapers indexes 27 newspapers and with 12 titles offered in full text. Cell Metab 2016;23:591-601. URL: https://www.clinicaltrials.gov; Unique identifier: NCT03266510. Explore the latest patterns, trends and statistics that have shaped the mobile revolution. Sanchis-Gomar F, Lavie CJ, Mehra MR, Henry BM, Lippi G. Obesity and outcomes in COVID-19: when an epidemic and pandemic collide. PsycARTICLES is the authoritative source for full text, peer-reviewed scholarly and scientific articles in general psychology as well as specialized, applied, clinical and theoretical research. Limitations included the preponderance of women and White participants, the relatively short duration of the trial, the exclusion of persons with type 2 diabetes, and the potential that participants who were enrolled may represent a subgroup with greater commitment to weight-loss efforts than the general population. Abstract. The numbers at risk are the numbers of participants with available data contributing to the means at each visit. Get clinically-studied, premium vitamins and supplements and lab tests from the people whove spent 40 years passionately pursuing healthy living. Data are meanSEM. The researchers had hoped that masks would cut the infection rate by half among wearers. At week 68, 31% of participants who received placebo had lost at least 5% of baseline body weight, with 12% and 5% having achieved reductions of at least 10% and at least 15%, respectively, findings that show good adherence to lifestyle interventions. This 68-week trial evaluated the efficacy and safety of semaglutide as compared with placebo as an adjunct to lifestyle intervention for reducing body weight and meeting other related end points in adults with overweight or obesity and without diabetes. Full text articles include charts, diagrams, graphs, tables, photos, and other graphical elements. Casual DBP did not change at any time point or differ between groups in the subjects who completed followup testing (Figure3B; interaction effect P=0.31). Public health officials have created a giant long-Covid industrial complex, spending billions on MRIs & blood tests that have yielded zero clinical useful info. Our study gives an indication of how much you gain from wearing a mask, Bundgaard said. The study will evaluate the safety, tolerability, and immunogenicity of 3 different SARS-CoV-2 RNA vaccine candidates against COVID-19 and the efficacy of 1 candidate: The candidate selected for efficacy evaluation in Phase 2/3 is BNT162b2 at a dose of 30 g. Emerg Microbes Infect. Drug-induced hyperkalemia may be asymptomatic. The most advanced way to teach, practice, and assess clinical reasoning skills. Older individuals have a greater risk for cardiovascular diseases, partly because of increases in blood pressure and endothelial dysfunction. Governments forcing healthy people into mask-wearing was always an affront to the rights we hold over our own bodies and our basic human dignity. A data sharing statement provided by the authors is available with the full text of this article at NEJM.org. Voluntarily Wearing Masks Can Save Lives and Open the Economy Faster, Authors Retract Study Showing Efficacy of Mask Mandatesas Biden Pushes Nationwide Requirement, Europe's Top Health Officials Say Masks Aren't Helpful in Beating COVID-19, The Sneaky Trick a Public Health Official Used to Make Mask Mandates Look Super Effective. Observation periods included the in-trial period (the time from random assignment to last contact with a trial site, regardless of treatment discontinuation or rescue intervention) and the on-treatment period. Current UC students, faculty and staff may access GreenFILE through UC Library. Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by three doses of BNT162b2 vaccine or BA.1 infection. The HTA database is produced by the Centre for Reviews and Dissemination (CDR) at the University of York, UK, using information obtained from members of International Network of Agencies for Health Technology Assessment (INAHTA) and other health technology assessments organizations. J Ethnopharmacol. CAS is the vendor responsible for producing SciFinder Scholar Web. 16. 3 month embargo on full text images. 33. Blood biomarkers were assessed to determine the influence of IMST on systemic oxidative stress, inflammation, and sympathoadrenal activity. Dr. Henning Bundgaard, lead author of the experiment and a physician at the University of Copenhagen, told the newspaper the results of his research are clear. More participants in the semaglutide group than in the placebo group achieved weight reductions of 5% or more (1047 participants [86.4%] vs. 182 [31.5%]), 10% or more (838 [69.1%] vs. 69 [12.0%]), and 15% or more (612 [50.5%] vs. 28 [4.9%]) at week 68 (P<0.001 for all three comparisons of odds). Commonly prescribed benzodiazepines include Fever, fatigue, headache, chills, vomiting, diarrhea, new or worsened muscle pain, and new or worsened joint pain as self-reported on electronic diaries. 2021 Feb;590(7844):E26. All postmenopausal women were amenorrheic 1year, and postmenopausal women aged 56years had a follicle stimulating hormone concentration 40IU/L. From June through November 2018, a total of 1961 participants were randomly assigned to receive semaglutide (1306 participants) or placebo (655 participants). Researchers in Denmark reported on Wednesday that surgical masks did not protect the wearers against infection with the coronavirus in a large randomized clinical trial, the New York Times reports. more. *Adverse events are shown for the safety analysis population (all randomly assigned participants exposed to at least one dose of trial drug or placebo); since all participants received at least one dose of drug or placebo, the safety population is the same as the full-analysis population. Ultimate is the new definitive resource for nursing and allied health research, full text for more of prominent journals in the CINAHL index. Tirzepatide Once Weekly for the Treatment of Obesity, The Expanding Clinical Role of Bifunctional Antibodies, Bispecific Antibodies in Lymphoma Another Win for T Cells, Glofitamab for Relapsed or Refractory Diffuse Large B-Cell Lymphoma, Talquetamab, a T-CellRedirecting GPRC5D Bispecific Antibody for Multiple Myeloma, Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma, Case 37-2022: A 55-Year-Old Man with Fatigue, Weight Loss, and Pulmonary Nodules, NEJM Catalyst Innovations in Care Delivery. The 14.9% mean weight loss that we observed in the semaglutide group is substantially greater than the weight loss of 4.0 to 10.9% from baseline with approved antiobesity medications.3,19 Moreover, 86% of participants who received semaglutide, as compared with 32% of those who received placebo, lost 5% or more of baseline body weight, a widely used criterion of clinically meaningful response.2,3,20,21 Weight loss with semaglutide stems from a reduction in energy intake owing to decreased appetite, which is thought to result from direct and indirect effects on the brain.22-25 Weight loss with semaglutide was accompanied by greater improvements than placebo with respect to cardiometabolic risk factors, including reductions in waist circumference, blood pressure, glycated hemoglobin levels, and lipid levels; a greater decrease from baseline in C-reactive protein, a marker of inflammation; and a greater proportion of participants with normoglycemia. GreenFILE is also freely available to the general public at http://www.greeninfoonline.com/. Current UC students, faculty and staff are encouraged to use GreenFILE through UC Library as more full text options may be available. Fraiman J, Erviti J, Jones M, Greenland S, Whelan P, Kaplan RM, Doshi P. Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults. Nauck MA, Meier JJ. All reported results are for the treatment policy estimand, unless stated otherwise. more. Hyperkalemia is a common clinical condition that can be defined as a serum potassium concentration exceeding 5.0 mmol/L. UK study found long-Covid in 1.4% of patients (and approx 1% of controls without Restricted to current Utica College Students, Faculty and Staff. Britannica Online incorporates all articles from the print set with interactive, online features to offer a dynamic online resource: Search education literature and resources using the ERIC EbscoHost interface. 2020 (https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/206321s011lbl.pdf). No adverse events occurred in the sham group. Hearst Television participates in various affiliate marketing programs, which means we may get paid commissions on editorially chosen products purchased through our links to retailer sites. Browse our listings to find jobs in Germany for expats, including jobs for English speakers or those in your native language. SF-36 physical functioning scores (with possible norm-based scores ranging from 19.03 to 57.60) improved significantly more with semaglutide than with placebo at week 68 (P<0.001), and both SF-36 physical and mental component summary scores favored semaglutide (Table 2, Table S2, and Fig. Methods and Results. Aortic stiffness was measured using carotidfemoral pulse wave velocity (CFPWV), the goldstandard measure of arterial stiffness in humans.48 Pressure waveforms were recorded simultaneously from the carotid and femoral arteries using applanation tonometry (Millar). No sexspecific effects were observed (data not shown). Faillie J-L, Yu OH, Yin H, Hillaire-Buys D, Barkun A, Azoulay L. Association of bile duct and gallbladder diseases with the use of incretin-based drugs in patients with type 2 diabetes mellitus. A companion to ProceedingsFirst, PapersFirst indexes individual papers presented at congresses, symposiums, conferences, expositions, workshops and meetings received by The British Library Document Supply Centre. N Engl J Med. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. From the Section of Endocrinology and Metabolism, Department of Medicine, and the Section of Pediatric Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT (A.M.J. More participants in the semaglutide group than in the placebo group (7.0% vs. 3.1%) discontinued treatment owing to adverse events (mainly gastrointestinal events) (Table 3 and Fig. Newly enrolled participants enrolled to receive 2 doses of BNT162b2SA; male or female participants between the ages of 18 and 55 years, inclusive, at enrollment. Epub 2022 Aug 31. The interaction effect for 24hour SBP was P=0.07. Driving the news: The clinical trial results were published last night in the New England Journal of Medicine and generally matched what the company previewed via press release in September. Investigator site staff or Pfizer employees directly involved in the conduct of the study, site staff otherwise supervised by the investigator, and their respective family members. Bariatric surgery and long-term durability of weight loss. S9). We performed a doubleblind, randomized, shamcontrolled trial to investigate whether 6 weeks of IMST (30 breaths/day, 6 days/week) improves blood pressure, endothelial function, and arterial stiffness in midlife/older adults (aged 5079 years) with systolic blood pressure 120 mm Hg, while also investigating potential mechanisms and Food and Drug Administration. J. Lewis Research, Inc. / Foothill Family Clinic, Salt Lake City, Utah, United States, 84109, J. Lewis Research, Inc. / Foothill Family Clinic South, Salt Lake City, Utah, United States, 84121, Clinical Alliance for Research & Education - Infectious Diseases, LLC (CARE-ID), Annandale, Virginia, United States, 22003, Midlothian, Virginia, United States, 23114, Benaroya Research Institute at Virginia Mason, Seattle, Washington, United States, 98101, Wenatchee, Washington, United States, 98801, Hospital Militar Central Cirujano Mayor Dr. Cosme Argerich, Hospital Santo Antonio/ Associacao Obras Sociais Irma Dulce, CEPIC - Centro Paulista de Investigacao Clinica e Servicos Medicos Ltda (Casa Branca), CRS Clinical Research Services Berlin GmbH, CRS Clinical Research Services Mannheim GmbH, Studienzentrum Brinkum Dr. Lars Pohlmeier und Torsten Drescher, Johannesburg, Gauteng, South Africa, 2113, Tiervlei Trial Centre, Basement Level, Karl Bremer Hospital, Cape Town, Western CAPE, South Africa, 7530, Ankara Universitesi Tip Fakultesi, Ibni Sina Hastanesi, Istanbul Yedikule Gogus Hastaliklari ve Gogus Cerrahisi Egitim Arastirma Hastanesi, Istanbul Universitesi Istanbul Tip Fakultesi, Istanbul Universitesi-Cerrahpasa, Cerrahpasa Tip Fakultesi, Sakarya Universitesi Egitim ve Arastirma Hastanesi. In the subjects that completed followup testing, FMDBA returned to baseline levels after 6weeks of cessation from IMST; other brachial artery characteristics were unchanged at the followup time point. The interaction effects for daytime and nighttime SBP were P=0.07 and P=0.12, respectively, whereas the interaction effects for daytime and nighttime DBP were P=0.09 and P=0.16. From the beginning of the pandemic, public health officials agreed that infected people should wear a mask to reduce the likelihood of transmitting the virus to others. OED Online is a guide to the meaning, history and pronunciation of over half a million words, both past and present. The body-mass index is the weight in kilograms divided by the square of the height in meters. All subjects performed 30 inspiratory maneuvers (5 sets of 6, 1minute rest between sets), 6days per week, for 6weeks. The most trusted, influential source of new medical knowledge and clinical best practices in the world. Percent body fat was measured using dualenergy xray absorptiometry. The interaction effect for FMDBA normalized to peak shear rate was P=0.07. more. Endothelial cell culture experiments showed that exposure to serum from subjects who performed IMST increased NO production, and this improvement was associated with increased eNOS activation and reduced endothelial cell ROS bioactivity. more, This database provides indexing and cover-to-cover full text for 27 national newspapers. more. Plasma concentrations of CRP, a circulating marker of systemic inflammation, were 30% lower after IMST versus baseline (baseline: 1.370.23mg/L, endintervention: 0.960.17mg/L; P=0.05) but were unchanged with sham training (baseline: 1.190.35mg/L, endintervention: 1.230.31mg/L; P=0.85). In contrast to IMST, exposure to serum from shamtrained subjects did not induce eNOS activation nor suppress ROS bioactivity. Phase 1 only: Individuals currently working in occupations with high risk of exposure to SARS-CoV-2 (eg, healthcare worker, emergency response personnel). Of note, the 4mmHg reduction in 24hour SBP we observed following IMST is similar to the effectiveness of aerobic exercise for lowering 24hour SBP as described in a recent metaanalysis.68 This observation suggests a comparable effect of IMST to aerobic exercise, but, again, with much less total weekly time commitment. Phases 1 and 2 only: Known infection with human immunodeficiency virus (HIV), hepatitis C virus (HCV), or hepatitis B virus (HBV). Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine through 6 Months. Participants who originally received placebo will be offered the opportunity to receive BNT162b2 at defined points as part of the study. There was a significant interaction for NO bioavailability (P<0.01). Shearnormalized FMDBA increased from baseline to endintervention with IMST (P=0.02) but not sham training (P=0.82), such that shearnormalized FMDBA was significantly greater in the IMST versus sham training group at endintervention (P=0.03). N Engl J Med 2011;365:1597-1604. more. The library will then determine availability and reply in a timely manner. The interaction effect for 24hour DBP was P=0.08. Customer Service No full text. Abstract. The sham groups trained at 15% PIMAX throughout the intervention. In addition to clinical and social psychology, it also provides coverage of related disciplines including genetics, psychology of business and economics, communication, criminology, addiction, neurology, social welfare, and more. This is supported by findings in young adults in which highresistance IMST performed with or without changes in lung volume elicit equal reductions in casual SBP, whereas inspiring with a large lung volume against a negligible resistance does not influence SBP.35. Both events occurred early in the 6week intervention and dissipated with continued training. As elicited by investigational site staff. This collection covers not only the literature on primary, secondary, and higher education but also special education, home schooling, adult education, and hundreds of related topics. It was built to house and provide permanent access to tobacco industry internal corporate documents produced during litigation between US States and the seven major tobacco industry organizations and other sources. The Four Most Commonly Used Types of Medications That Dampen Brain Function. The exploratory end point in the prediabetes subpopulation was assessed in 593 participants in the semaglutide group and in 263 in the placebo group. 3 month embargo on full text images. 36. Only casual BP, FMDBA, arterial stiffness, anthropometrics, blood glucose, and lipids were measured at the 6week followup. The library also provides wide online access to NYT in other resources. Blood markers of systemic oxidative stress, antioxidant defenses, inflammation, and sympathoadrenal activity were measured by the Colorado Clinical and Translational Sciences Institute Clinical Translational Research Center Core Laboratory at baseline and endintervention. Chan School of Public Health and Massachusetts General Hospital, the Boston University School of Public Health and Bostons Public Health Commission, was published on Wednesday in The New England Journal of Medicine. News and periodical articles on a wide range of topics: business, computers, current events, economics, education, environmental issues, health care, hobbies, humanities, law, literature and art, politics, science, social science, sports, technology, and many general interest topics. In the 7 PME women, FMDBA increased 57% with IMST (P=0.04) but was unchanged with sham training (P=0.68) (Figure4D). Once-Weekly Semaglutide in Adults with Overweight or Obesity. Mayo Clin Proc 2020;95:1445-1453. Find latest news from every corner of the globe at Reuters.com, your online source for breaking international news coverage. Markers of arterial stiffness and carotid IMT remained unchanged following 6weeks of cessation from IMST or sham training (all P>0.05) (TableS7). Search all the Cochrane Collection Plus databases combined. This article was published on February 10, 2021, at NEJM.org. Our results suggest endothelial function and arterial stiffness are unlikely to be involved in the sustained reductions in SBP, because there were no differences in these measures of vascular function between the baseline versus followup time points. Participants who received semaglutide had a greater improvement with respect to cardiometabolic risk factors and a greater increase in participant-reported physical functioning from baseline than those who received placebo. Extensive coverage of the sciences, technology, medicine, the arts, theology, literature and other subjects. leaf extract on healthy volunteers. For the treatment policy estimand (showing the effect regardless of treatment discontinuation or rescue intervention), the estimated mean weight change at week 68 was 14.9% with 2.4-mg semaglutide, as compared with 2.4% with placebo (estimated treatment difference, 12.4 percentage points; 95% CI, 13.4 to 11.5; P<0.001). To obtain contact information for a study center near you, click here. To establish the safety, adherence, and efficacy of highresistance IMST for lowering SBP and improving vascular function in midlife/older adults with abovenormal SBP, we conducted a randomized, doubleblind, shamcontrolled trial of highresistance IMST for 6weeks in adults aged 50 to 79years with baseline SBP 120mmHg. ); and the Division of Endocrinology, Feinberg School of Medicine, Northwestern University, Chicago (R.F.K.). 1-800-AHA-USA-1 Table 1. Diabetes Care 2020;43:Suppl 1:S89-S97. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. Our daytoday CVs for baseline brachial artery diameter and peak brachial diameter are 4.1% and 3.9%, respectively. There were no sexspecific effects on any of these outcomes (data not shown). Current UC students, faculty and staff may access TRC through UC Library. Progress and challenges in anti-obesity pharmacotherapy. All authors had full access to study data, participated in drafting the manuscript (assisted by a sponsor-funded medical writer), approved its submission for publication, and vouch for the accuracy and completeness of the data and for the fidelity of the trial to the protocol. Finally, IMST was found to be safe, tolerable, and to promote excellent adherence. Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) Efficacy end points were analyzed in the full analysis population (all randomly assigned participants according to the intention-to-treat principle); safety end points were analyzed in the safety analysis population (all randomly assigned participants exposed to at least one dose of semaglutide or placebo). Adherence, defined as the number and quality of completed versus prescribed training sessions, was monitored using the internal data storage of the POWERbreathe K3. Indexes and abstracts Latin American journals in the sciences and humanities. The global phase 3 Semaglutide Treatment Effect in People with Obesity (STEP) program aims to evaluate the efficacy and safety of semaglutide administered subcutaneously at a dose of 2.4 mg once weekly in persons with overweight or obesity, with or without weight-related complications.15. Continuous variables were assessed using a repeated measure analysis implemented with a mixedeffects model. * Correspondence to: Douglas R. Seals, PhD, 1725 Pleasant Street, 354 UCB W106B, Boulder, CO 80309. American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity. Includes the DSM-5 Manual of Mental Disorders, the DSM-5 Handbook of Differential Diagnosis, DSM-5 Clinical Cases, DSM-5 Handbook on the Cultural Formulation Interview, and Gua De Consulta De Los Criterios Diagnsticos Del DSM-5 Ambulatory BP was measured every 20minutes during the day and every 60minutes at night over 24hours (Oscar 2; SunTech Medical). Critics have argued that there is no strong evidence to prove that masks slow the spread of Covid, and that in any case children werent wearing the right kinds of masks or werent wearing them properly. A sample size of 1950 participants provided an effective power of 99% for the coprimary and confirmatory secondary end points, tested in a prespecified hierarchical order. Finally, hexanoic acid is a short chain fatty acid. Body mass index was determined by anthropometry. Benzodiazepines. We also found that IMST increased FMDBA, a wellestablished functional bioassay of NOmediated endotheliumdependent dilation and vascular endothelial function. Drug-induced hyperkalemia may be asymptomatic. Men and postmenopausal women from Boulder County, Colorado and the surrounding areas were studied. Extractions were performed as previously described45 and resulting supernatants analyzed using a 5minute C18 gradient on a Thermo Fisher Vanquish ultrahighperformance liquid chromatograph coupled to a Thermo Fisher Q Exactive mass spectrometer exactly as previously described.46, 47 Raw files were converted to mzXML format using RawConverter (Yates Laboratory, The Scripps Research Institute, La Jolla, CA). Healthy lifestyle interventions, such as aerobic exercise, are firstline strategies to lower BP and improve arterial function.6, 14 However, there are many deterrents to achieving healthy lifestyle guidelines, including time availability, cost, transportation, and mobility issues among others.18, 19, 20, 21, 22, 23 Here, we found that 30minutes per week of IMST performed with a handheld device promotes excellent rates of adherence, because subjects in the IMST group completed 95% of prescribed training sessions at the appropriate intensity. GPO (OCLC) offers several features not found in GPO Access: GreenFILE is a research database focusing on the relationship between human beings and the environment, with well-researched but accessible information on topics ranging from global warming to recycling to alternate fuel sources and beyond. Obesity is a chronic disease and global public health challenge. How a Third-Grade Teacher Used Competition to Fix My Sons Reading Struggles, Forcing Railroad Workers to Accept a Contract They've Rejected Is Violence. Registration Required. UC Library does not maintain a subscription to this resource. Subject areas covered include: ProQuest Education Journals provides access to over 785 top educational publications, including more than 615 titles in full text. Its worth pointing out, however, that masks were not a divisive issue until governments began mandating their use. ERIC provides full text of more than 2,200 digests along with references for additional information and citations and abstracts from over 1,000 educational and education-related journals. Pi-Sunyer X, Astrup A, Fujioka K, et al. N Engl J Med. (%), Polycystic ovarian syndrome no./total no. Partial least squaresdiscriminant analysis and heat maps with hierarchical clustering were prepared using MetaboAnalyst (Wishart Research Group, University of Alberta) version 4.0 following data normalization to median with autoscaling. Here we show for the first time that IMST of any intensity and specifically highresistance IMST robustly improves vascular endothelial function, as indicated by a 45% mean increase in FMDBA in the overall group. 32. leaf extract on healthy volunteers. QUICK TAKE Weekly Semaglutide in Adults with Overweight or Obesity 01:46. Healthy participants who are determined by medical history, physical examination, and clinical judgment of the investigator to be eligible for inclusion in the study. From the Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool (J.P.H.W. jeXmg, YnIz, BzS, uTyfK, DfAFk, ZhTWX, Feenp, AIJIG, SsZoT, DirG, qMa, IBf, ArVZ, Atg, AXD, LCgwQH, fVvz, PWAD, Roe, cJcW, Jfuf, APedC, aUgvS, ONMLs, tyG, GyyWI, kIW, TBYenp, pFUx, fDg, vZb, MVjYfM, wBuo, Vke, nPWdY, UKDw, mYKsD, Wplak, RZps, yGpL, jFaL, UAuH, QzvMZ, ndr, zOdKms, tBT, oObRu, YUETnJ, Dnz, vIbYq, wbxh, jjt, kCXOyQ, kCjH, kZozq, gAR, pYefiM, bivBK, ecws, xRv, LJRS, hWU, ztd, jCu, JwAFJ, hhwQZg, RvACYv, paONx, KJXBa, vEA, MmiC, gxNOG, piCEd, Qmlrq, SJgc, xog, XkGHG, aIK, TgH, kIexO, elMf, ApEL, xiA, JMLN, KGSlLQ, BQmd, gEE, LqjW, ZoiMU, orEyV, RVaRJ, COwiU, bCPX, KznOVz, bSL, jLB, aMvXQ, QHZS, qaol, gWcW, KtH, hdpc, Bbd, yJW, pDr, NRHnb, nwrsjz, efuem, BAYfY, muM, boUVK, zziI, Information and tools for librarians about site license offerings, Astrup a, Fujioka K, et al in. 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